Exponential DNA replication by laminar convection.

نویسندگان

  • Dieter Braun
  • Noel L Goddard
  • Albert Libchaber
چکیده

It is shown that laminar thermal convection can drive a chain reaction of DNA replication. The convection is triggered by a constant horizontal temperature gradient, moving molecules along stationary paths between hot and cold regions. This implements the temperature cycling for the classical polymerase chain reaction (PCR). The amplification is shown to be exponential and reaches 100,000-fold gains within 25 min. Besides direct applications, the mechanism might have implications for the molecular evolution of life.

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عنوان ژورنال:
  • Physical review letters

دوره 91 15  شماره 

صفحات  -

تاریخ انتشار 2003